A beautiful woman (series star JAIMIE ALEXANDER) is found in Times Square, her memory erased, her body fully covered in a series of coded tattoos. But as "Jane Doe" and the FBI team who discovered her -- including agents Kurt Weller (series star SULLIVAN STAPLETON), Edgar Reade (series star ROB BROWN), Tasha Zapata (series star AUDREY ESPARZA) and the tech savvy Patterson (series star ASHLEY JOHNSON) -- work to decipher, investigate and solve the complex treasure map of her body, an ever-widening web of conspiracy and corruption is revealed, as is the truth behind Jane Doe's real identity and the identity of the people who sent her to the FBI in the first place. But what does this nefarious group really want? And can Jane and her teammates stop them in time?

In the season premiere, Jane escapes CIA custody, only to be recaptured by the team who convince her to become a triple-agent within her old terrorist organization, where she unlocks some major secrets from her past.  Meanwhile, recent betrayals from both sides threaten to tear her and the team apart for good.  LUKE MITCHELL, MICHELLE HURD and ARCHIE PANJABI join the cast.